Antibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones

Antibacterial, antifungal and in vitro antileukaemia activity of metal complexes with thiosemicarbazones

1-phenyl-3-methyl-4-benzoyl-5-pyrazolone 4-ethyl-thiosemicarbazone (HL) and its copper(II), vanadium(V) and nickel(II) complexes: [Cu(L)(Cl)]·C₂H₅OH·(1), [Cu(L)₂]·H₂O (2), [Cu(L)(Br)]·H₂O·CH₃OH (3), [Cu(L)(NO₃)]·2C₂H₅OH (4), [VO₂(L)]·2H₂O (5), [Ni(L)₂]·H₂O (6), were synthesized and characterized. The ligand has been characterized by elemental analyses, IR, (1) H NMR and (13) C NMR spectroscopy....

Antifungal Activity of Some Thiosemicarbazones and Their Copper Complexes.

An extensive literature has developed in recent years in the field of chelate compounds with special reference to their antimicrobial properties. Thus, for example, the copper chelate of oxine (8-hydroxyquinoline) has been the subject of numerous investigations (Hollingshead, 1956). Thiosemicarbazones (TSC), which are compounds capable of forming chelates, have been investigated by Domagk (1950...

Synthesis and characterization of some new Cu(II), Ni(II) and Zn(II) complexes with salicylidene thiosemicarbazones: antibacterial, antifungal and in vitro antileukemia activity.

Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1-32) with salicylidene thiosemicarbazones (H₂L¹-H₂L¹⁰) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C6H5). The characterization of the new for...

Thiosemicarbazones and Their Transition Metal Complexes

In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates

The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacteria...